Autoimmune Diseases in mRNA-Vaccinated People

“Frameshift” mutation is a disastrous consequence of the mRNA COVID vaccines. The wild card proteins that result are provoking new autoimmune disease, according to recent studies.

Have you ever typed on a keyboard in a dark room?   “Good morning” can turn out as “Hppf ,pt,momh” if each finger has moved one key to the right.  Now apply that outlandish translation to genetics.

If you are familiar with introductory genetics, you may want to skip down to the section on how mRNA vaccines are damaging human genetic machinery.  Otherwise, I summarize some pertinent background information for a lay audience over the following paragraphs.

Genetics refresher and introduction

Over years of clinical practice, I have opined to patients that human proteins, especially collagen, are the bricks and mortar, so to speak, that we are made of.  Proteins are the end-products of our genetic production apparatus.  Collagen is our main structural protein.  What you see in the human body is comprised of dozens of types of collagen primarily. That is, Type I collagen forms teeth and other bone, as well as skin. Type II collagen comprises cartilage, and so forth.  Proteins are the basic molecular unit forming the physical basis of the body, and this has been observed for well over a century.  [1] 

As the body grows and remodels itself over the lifespan, our cells are formed and die and get replaced, some faster and some slower, resulting in all cells in the body being replaced every several years. [2]  Those microscopic cells, as well as the large macroscopic structures that we see, are all comprised of proteins (plus some other types of molecules).

Therefore, the formation of proteins is essential to life and the continuation of an individual’s life.  One of the most important functions of each cell in the body is to house the production and assembly of proteins.  That factory in the cell is the endoplasmic reticulum (ER), and the production units are ribosomes, bead-like items attached to the ER.  This process of producing proteins using RNA molecules as templates to make proteins is known as translation, and it is constant throughout the body, all though life.

The main protein manufacture paradigm is one-dimensional.  It is a string of code.  The units produced by those codes are amino acids.  Amino acids are simply the pieces, of which the whole protein structure is made.  (Later, that gets folded into a three-dimensional shaped protein.)  The amino acids appear in a string, as they come off the ribosome assembly apparatus.  The protein production vocabulary is dense at first, but the concept is simple: a factory that specializes in strings of beads in very specific order.

Amino acids are units from which proteins are assembled.  There are 20 different amino acids that can be made in the body.  (Other essential amino acids must come from the diet, because we cannot make them.) The formula for an amino acid is a codon, which is a string of three nucleic acids.  There are four different base molecules that comprise RNA.  They are:

Each string of three bases is a codon, and each codon produces a different amino acid. For example, “UGG” is not only what the reader might be muttering while reading about these details of genetic machinery, but also UGG (uracil-guanine-guanine) is the codon for the amino acid tryptophan, which is known to produce a relaxing sensation after a turkey meal, because turkey is high in tryptophan, and tryptophan is the precursor of both serotonin and melatonin, which might come in handy for restful sleep.

Here’s where the mRNA vaccines create problems in the genetic machinery.

mRNA vaccines delivered enough packets of mRNA, enclosed in trojan horse lipid nanoparticles, about 40 trillion such packets per dose, to possibly penetrate every one of the body’s roughly 30 trillion cells.   Each packet was intended to re-direct the human cell’s genetic machinery to produce spike proteins.  Yes, spike proteins are toxic and create problems, but the inventors’ thinking was that the irritating nature of those spikes would stimulate the immune system to produce antibodies against them, which would also work against naturally acquired spike proteins that are characteristic of coronaviruses such as SARS-CoV-2.  Or so the story went.  This was the main selling point of the mRNA vaccines.

However, the catch is that this particular mRNA interferes with the body’s protein-making machinery in unanticipated and uncontrolled ways, and it does so as follows:

Modified mRNA substituted a synthetic pseudouracil for the nucleic acid uracil.  This was done in order to have ribosomes skip over the unreadable pseudouracil, and to make an amino acid from the next three nucleic acids.  Therefore, a completely different amino acid is made.  Have you ever typed on a keyboard in a dark room?  If you have, and your hands are moved over just one key, then “Good morning” becomes “Hppf ,pt,momh,” if each finger sits one key too far to the right.  That is a similar frameshifting to what is happening with the pseudouracil in the mRNA injections. 

So what was intended or alleged to be code for spike proteins, the alleged objective of the shots, now becomes something wildly different. 

Worse still, because the codons are in a linear sequence, not only is the first codon to be affected by this error, but each of the subsequent codons also are quite different. So the reading frame of each codon triplet shifts. Therefore, as the growing sequence of these errors accumulate down the chain, a vastly different sequence of amino acids makes a very different protein than the spike protein, which was intended, or at least alleged. 

In this way, the following sequence:

UGC GUG CGA CCU can become [ignored methyl-U] GCG UGC GAC CU_

The unaffected chain of amino acids would then be:

 Cysteine – Valine – Arginine - Proline

now becoming:

Alanine – Cysteine - Aspartic acid - Leucine, which will result in a vastly different protein.  This is because human proteins average hundreds of amino acids long, and the errors at the beginning of the chain just keep carrying through all the way to the end. 

The ultimate problem is that once proteins appear foreign (non-self) enough to the immune system, they are more likely to be subject to attack by cells of the immune system: macrophages, neutrophils, natural killer cells, cytotoxic T cells are all out to get foreign proteins and microbes.  Instead of maintaining an effective vigilance and defense against invading pathogens, such as bacteria and viruses, the immune system now becomes tasked with fighting off a confusing array of enemies within, that is bizarrely atypical proteins.

Autoimmune effects that are becoming apparent three years after peak vaccine uptake

Last week, researchers at the Universities of Cambridge and Oxford found that some of the proteins produced by the mRNA vaccines turned out to be aberrant, different than the intended spike proteins. [3]  They ruled out this problem in COVID infection, as well as in the non-mRNA vaccines, such as the Astra Zeneca vaccine.

It was already known since at least 2011 that pseudo uridine could have this effect of misreading codons. [4]

The Cambridge researchers suspected that the problematic proteins could show up in T-cells, and they vaccinated mice with the Pfizer BNT162b2 vaccine.  The vaccinated mice showed “off-target immunity,” which was found to be caused by the +1 ribosomal frameshifting.  This is what is commonly known as autoimmune dysfunction. The unvaccinated mice did not have this problem.

As a consequence of this frameshifting, “presentation of +1 frameshifted products could activate T cells that target host cells.” [5]  Indeed, this study showed that “cellular immunity to +1 frameshifted products can occur following vaccination.”

COVAD is a series of surveys formally named “COVID-19 vaccination in autoimmune diseases.”  These multinational surveys, reported by 26 authors, examine autoimmune effects from the COVID vaccines. [6]  Of 17,512 respondents to the survey, 10,041 were “fully vaccinated against COVID-19,” primarily with Pfizer (69%), and to a lesser extent Moderna, then Astra Zeneca.  Of the vaccinated cohort, two-thirds reported having a diagnosis of either systemic sclerosis or other systemic autoimmune and inflammatory disorders.

A study in the journal Autoimmunity this month supports the above findings.  Laboratory results are consistent with findings of autoimmune diseases in those vaccinated with mRNA vaccines, both the Pfizer and Moderna brands.  A study of 155 healthcare workers found dose-dependent effects on the autoimmune marker known as antinuclear antibodies (ANA).  This marker has been correlated with rheumatoid arthritis, lupus, scleroderma and other serious autoimmune diseases.  The rate of positive ANA results was found to be directly correlated with the number of mRNA vaccine doses received by the healthcare workers. [7]

The above findings reinforce the urgency of eliminating the mRNA vaccines from use with humans or other species.

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[1] TH Huxley.  De partibus similaribus.  Oct 1853.  Br Foreign Med Chir Rev.  12 (24).  285-314.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5186153/

[2] P Heinke, F Rost, et al.  Diploid hepatocytes drive physiological liver renewal in adult humans.  Jun 15 2022.  Cell Systems.  13.  499-507.  https://www.cell.com/cell-systems/pdf/S2405-4712(22)00171-5.pdf

[3] T Mulroney, T Poyry, et al.  N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting.  Dec 6 2023.  Nature.  https://www.nature.com/articles/s41586-023-06800-3

[4] J Karijolich, Y Yu.  Converting nonsense codons into sense codons by targeted pseudouridylation.  Jun 16 2011.  Nature.  474 (7351)  395-398.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381908/

[5] Ibid.  Mulroney, et al. https://www.nature.com/articles/s41586-023-06800-3

[6] S Panchawagh, D Bohdana, et al.  Delayed adverse events following COVID-19 vaccination in patients with systemic sclerosis and other autoimmune diseases: a substudy of the COVAD-2 cohort.  Sep 15 2023.  Rheum Intl.  43,2211-43,2220.  https://link.springer.com/article/10.1007/s00296-023-05441-z

[7] M Sacchi, C Pelazza, et al.  The onset of de novo autoantibodies in healthcare workers after mRNA based anti-SARS-CoV-2 vaccines: a single centre prospective follow-up study.  Dec 2023.  56 (1): 2229072.   https://pubmed.ncbi.nlm.nih.gov/37381619/