Cancer Pathways From the COVID Vaccines

In the pre-COVID era there were 7 major ways in which cancer established itself. Since the mRNA COVID vaccines, there are about 7 additional ways that are making cancer even harder to fight.

It has now been three years since peak COVID vaccine uptake.  In that time, many clinical observations have been made regarding the rise of “turbo cancers” in the COVID-vaccinated.  These reports are from oncologists and pathologists who have observed an influx of new cancer patients with accelerated growth of aggressive cancers.  Oncologist William Makis MD reports turbo cancers even in fetuses, an unheard of event prior to the COVID vaccine era. [1]  Regarding other age groups, Professor of Oncology Angus Dalgleish MD wrote to the British Medical Journal: “As a practising oncologist I am seeing people with stable disease rapidly progress after being forced to have a booster . . .” [2] Dr. Dalgleish reports seeing especially B-cell based cancers flourish in his colleagues as well as patients, and he urged that the COVID vaccine program be stopped immediately.

In this paper, I examine the mechanisms of why there are now more and faster-growing cancers than before the COVID vaccine era, and several reasons why the disease process would be driven by mRNA COVID vaccination.

But first, a review of known carcinogenic processes from the pre-COVID vaccine era will establish a background for developments in the new era.

In 2001, John Boik described the seven major pro-cancerous enabling events as follows: [3]

1)    Genetic instability, as a vulnerability to mutation, which is the first event in tumor initiation;

2)    Abnormal gene expression, which makes proteins that promote cancer and that block the inhibition of cancer;

3)    Atypical and self-starting cell signal transduction, which enables the self-stimulation of cancer growth, as opposed to depending on growth factors from other cells;

4)    Atypical cell-to-cell signaling, which isolates a tumor from its neighboring cells metabolically.  This process cuts off the tumor from homeostatic mechanisms that would otherwise suppress its growth.  As a result, the tumor’s metabolic activity furthers the survival interests of the tumor, rather than the needs of the host’s body.

5)    Angiogenesis, which is the growth of new blood vessels, to facilitate hoarding of incoming fuels, sugars primarily, by the tumor.

6)    Invasion and metastasis, not only caused by the aggression of cancer’s hypermetabolic activity, but also from weak, previously injured and friable tissue;

7)    Evasion of immune cells, by means of camouflage (appearing as “self”) and counteractivity to the functions of immune system cells and cytokines.

Now, in the aftermath of peak COVID vaccine uptake, Irrgang et al addressed immunoglobulin changes seen after the mRNA vaccines.  The authors discussed an IgG4 shift that has received much attention as a potential cause of cancer. [4]   While that paper furthered understanding of how misplaced immune resources distract the immune system from important tasks generally, it does not address some of the worst carcinogenic threats posed by the COVID vaccines, which I discussed here a year ago [5] and will address more below.

Angues, et al list some of the pro-cancerous events seen post-mRNA vaccination as follows: [6]

1)    Lymphopenia, a depletion of white blood cells, that presumably would have otherwise attacked cancer cells, if not already overwhelmed by a large spike protein burden;

2)    Spike proteins’ pro-oncogene effects;

3)    Impaired Type I interferon response;

4)    Reverse transcription and integration of spike RNA into the human genome, changing DNA;

5)    Pro-inflammatory effects of lipid nanoparticles;

6)    Disruption of the RNA-G4 protein binding; and

7)    The generally pro-inflammatory effects of spike proteins.

Let’s examine each item on the above list.

(1)          Lymphopenia has been observed following both Pfizer [7] and Astra Zeneca [8] COVID vaccines.  Low lymphocytes, particularly low T cells, have correlated with cancer incidence, metastasis [9] and severity. [10]

(2)          Spike proteins have been shown to promote pro-cancerous molecules such as NF-κB, and interleukin-6. [11]  NF-κB has multiple pro-cancerous effects, including proliferation and invasion, as well as angiogenesis and distraction of the immune system cells. [12] High IL-6 is correlated with tumor relapse in breast cancers, among others. [13]

(3)          In a landmark paper, Seneff, Nigh, et al showed that reduction of Type I interferon by the mRNA vaccines is decisive in the impairment of downstream molecules and cells of the immune system that are needed to fight cancer. [14] This effect I think is the most thoroughly substantiated, as well as the most devastating, mechanism behind all of the pro-cancerous effects of the COVID vaccines shown to date, and has more plausible influence over a multitude of downstream processes than other mechanisms shown to date. [15]

In that last paper I summarized those effects here:

The very useful tool of making cancer recognizable to the immune system is key in defeating cancer, and Type I interferon is our most essential cytokine, and the best endogenous molecule known to be successful in that job. [16]  Significantly, those who acquired COVID disease naturally have been shown to dramatically up-regulate Type I interferon, [17] which is the opposite of what Seneff et al showed for the COVID-vaccinated, in which Type I interferon plummeted.

(4)          As far as the COVID mRNA vaccines changing DNA by reverse transcription and integration into the genome, this has been confirmed in liver tissue [18] [19]  and with the finding of Pfizer-specific genes in Pfizer-vaccinated subjects. [20]   But this was known to happen near the beginning of the COVID vaccination era, as Zhang et al wrote of this finding in May 2021. [21]

The problem is not only that human DNA becomes irreversibly changed by the edits made to it by the mRNA vaccines.  An even more worrisome problem is that a new genetic instability is introduced by this process. [22] Genetic instability is the first (or second) of several events leading to a new cancer.

(5)          Lipid nanoparticles, which are used to enclose the 40 trillion mRNA packets in one dose of a mRNA vaccine, are known for many years to be highly inflammatory [23] and toxic.[24] These cationic lipids cause damage to multiple organs, such as lungs and liver, as well as mitochondria, red blood cells and the white blood cells of our immune systems. [25]

Mitochondria are essential to the body’s defense against cancer.  Nobel Prize-winning biochemist Otto Warburg showed in 1931 that the metabolic pathway through the mitochondria is the normal and healthy metabolic pathway, whereas the alternate route for metabolism outside the mitochondria, anaerobic glycolysis, is the mechanism of cancer, how it lives and thrives.  There is enormous detail to the metabolic understanding of cancer and human defenses against it.  I discuss small parts of various metabolic sub-pathways in a series of videos. [26]  Thomas Seyfried PhD’s laboratory work explores this topic in great detail. [27]

(6)          Normal human gene expression has been found to be disrupted by abundant quadruplex (G4) formations.  For every four G4 formations in the naturally acquired SARS-CoV-2 spike protein, there are 19 in the Moderna vaccine, and nine in the Pfizer vaccine.  This G4 prevalence is associated with chaotic RNA binding, which in turn has been correlated with a number of disease conditions, including cancer progression. [28]  This has been shown to be the case specifically in breast cancer. [29]

(7)          Finally, spike proteins are highly inflammatory.  Inflammation is long considered as a precursor of several cancerous processes, partly through neutrophil activation [30] and their transformation to myeloid derived suppressor cells. [31]  The S2 unit of the spike protein seems to be particularly involved in the pro-cancerous process through interaction with the tumor suppressor protein p53 and BRCA 1 and 2.  [32]

It has now been three years since peak COVID vaccine uptake.  The Pfizer vaccine became available in the US and Israel in December 2020, followed swiftly by use of those and certain competitor vaccines in all populated continents except Africa.  Africa has stayed relatively free from both COVID and the COVID vaccines, in stark contrast. [33]

The pro-cancerous processes described above began with an irritant, a toxin, or rather a blueprint for a toxin.  That is, a foreign body is introduced into the body in a way that cannot be expelled. 

Credit: JUAN GAERTNER / SCIENCE SOURCE, in https://www.acepnow.com/article/how-the-covid-19-mrna-vaccines-work-and-some-current-concerns/

Then the immune and genetic reactions to the presence of that antigen are now seen to set in motion fractally extending consequences in several microscopic arenas that lead to full-blown macroscopic tumors.  Worse, the above carcinogenic processes synergistically strengthen cancer.  These problems must be resolved before mRNA technology is offered in any form to humans, and even then, only after informed consent that extensively discloses that platform’s many known hazards.

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[1] W Makis.  mRNA & pregnancy – Fetuses are developing cancers . . . Dec 2 2023. 

mRNA & Pregnancy - Fetuses are developing cancers. These may be Turbo Cancers. Worse yet: DNA contamination, contained within Lipid Nanoparticles (LNP), may be crossing the placenta into the fetus!

[2] A. Dalgleish.  Letter to Dr. Kamran Abbasi, Editor in Chief of BMJ, reported Nov 26 2022, in https://dailysceptic.org/2022/11/26/as-an-oncologist-i-am-seeing-people-with-stable-cancer-rapidly-progress-after-being-forced-to-have-a-booster/

[3] J Boik.  Natural Compounds in Cancer Therapy.  Book. Oregon Medical Press.  2001.  P.2.

[4] P Irrgang, J Gerling, et al.  Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination.  Dec 22 2022. Science.  8 (79).  https://www.science.org/doi/10.1126/sciimmunol.ade2798

[5] C Huber.  How COVID vaccines cause cancer.  Dec 29 2022.  The Defeat of COVID.  https://colleenhuber.substack.com/p/how-covid-vaccines-cause-cancer

[6] R Angues, Y Bustos.  SARS-CoV-2 vaccination and the multi-hit hypothesis of oncogenesis.  Dec 17 2023.  Cureus.  15 (12): e50703.  https://www.cureus.com/articles/209584-sars-cov-2-vaccination-and-the-multi-hit-hypothesis-of-oncogenesis#!/

[7] M Mulligan, K Lyke, et al.  Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults.  Nature. Aug 12 2020, 586:589-593.  https://www.nature.com/articles/s41586-020-2639-4

[8] P Folegatti, K Ewer, et al.  Safety and immunogenicity of the ChAdOxi nCoV-19 vaccines against SARS=-CoV-2: a preliminary report of a phase  1 / 2, single-blind, randomized controlled trial.  Lancet Aug 15 2020, 396:467-78. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31604-4/fulltext

[9] I Romero, C Garrido, et al.  T lymphocytes restrain spontaneous metastases in permanent dormancy.  Apr 1 2014.  Cancer Res.  74 (7).  https://aacrjournals.org/cancerres/article/74/7/1958/599437/T-Lymphocytes-Restrain-Spontaneous-Metastases-in

[10] C Ménétrier-Caux, I Ray-Coquard, et al.  Lymphopenia in cancer patients and its effects on response to immunotherapy: an opportunity for combination with cytokines?  Oct 8 2018.  BMJ.  https://jitc.bmj.com/content/7/1/85.info

[11] T Patra, K Meyer, et al.  SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiontensin II recedptor signaling in epithelial cells.  Dec 7 2020.  PLoS Pathogens.  https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009128

[12] K Taniguchi, M Karin.  NF-κB, inflammation, immunity and cancer: coming of age.  Jan 22 2018.  Nature. 18: 309-324.  https://www.nature.com/articles/nri.2017.142

[13] N Semesiuk, A Zhylchuk, et al.  Disseminated tumor cells and enhanced level of some cytokines in bone marrow and peripheral blood of breask cancer patients as predictive factors of tumor progression.  Dec 2013.  35 (4).  295-302.  https://pubmed.ncbi.nlm.nih.gov/24382441/

[14] S Seneff, G Nigh, et al.  Innate immune suppression by SARS-CoV-2 mRNA vaccinations:  The role of G-quadruplexes, exosomes, and microRNAs.  Jun 2022.  Food Chem Toxicol.  164: 113008.  https://www.sciencedirect.com/science/article/pii/S027869152200206X?via%3Dihub

[15] C Huber.  How COVID vaccines cause cancer.  Dec 29 2022.  The Defeat of COVID.  https://colleenhuber.substack.com/p/how-covid-vaccines-cause-cancer

[16] R Heise, Philipp Amann, et al.  Interferon alpha signalling and its relevance for the upregulatory effect of transporter proteins associated with antigen processing (TAP) in patients with malignant melanoma.  Jan 16 2016.  PLoS One.  11 (1)  e0146325.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703378/

[17] E Ivanova, J Devlin, et al.  SARS-CoV-2 mRNA vaccine elicits a potent adaptive immune response in the absence of IFN-mediated inflammation observed in COVID-19. Aug 23 2021.  medRxiv.  https://www.medrxiv.org/content/10.1101/2021.04.20.21255677v2

[18] H Merchant.  Comment on Aldén et al. intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT 162b2 in vitro in human liver cell line.  Apr 2022.  Curr Issues Mol Biol  44 (4):  1661-1663.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164063/

[19] M. Aldén, F Falla, et al.  intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT 162b2 in vitro in human liver cell line.  Jan 18 2022.  Curr Issues Mol Biol. 44 (3).  1115-1126.  https://www.mdpi.com/1467-3045/44/3/73

[20] K Dhuli, M Medori, et al.  Presence of viral spike protein and vaccinal spike protein in the blood serum of patients with long-COVID syndrome. 2023.  Eur Rev Med Pharmacol Sci.  https://www.europeanreview.org/wp/wp-content/uploads/013-019-2.pdf

[21] L Zhang, A Richards, et al.  Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues.  May 25 2021.  Proc Natl Acad Sci USA.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166107/

[22] K Acevedo-Whitehouse, R. Bruno.  Potential health risks of mRNA-based vaccine therapy: A hypothesis.  Feb 2023.  171: 111015.  https://www.sciencedirect.com/science/article/pii/S0306987723000117?via%3Dihub

[23] R Kedmi, N Ben-Arie, et al.  The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation.  Sep 2010.  31 (26).  6867-6875.  https://www.sciencedirect.com/science/article/abs/pii/S0142961210006459?via%3Dihub

[24] V Schmidt-Kruger.  Interview; Hearing #37 of German Corona Extra-Parliamentary Inquiry Committee. Jan 30 2021.  http://enformtk.u-aizu.ac.jp/howard/gcep_dr_vanessa_schmidt_krueger/

[25] S Cui, Y Wang, et al.  Correlation of the cytotoxic effects of cationic lipids with their headgroups.  2018. Toxicol Res. https://pubs.rsc.org/en/content/articlelanding/2018/tx/c8tx00005k#!divAbstract

[26] C Huber.  Cancer and biochemistry. 32 videos.  https://natureworksbest.com/cancer-biochemistry/

[27] T Seyfried.  Cancer as a Metabolic Disease.  Book. Publishdrive.  2012. 

[28] S Seneff, et al.  Ibid.

[29] R Hänsel-Hertsch, A Simeone, et al.  Landscape of G-quadruplex DNA structural regions in breast cancer.  Aug 3 2020.  Nature Genetics. 52: 878-883. https://www.nature.com/articles/s41588-020-0672-8

[30] A Ocana, C Nieto-Jiménez, et al.  Neutrophils in cancer: prognostic role and therapeutic strategies.  Aug 15 2017.  16 (137).  https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0707-7

[31] B Rapoport, H Steel, et al.  Role of the neutrophil in the pathogenesis of advanced cancer and impaired responsiveness to therapy.  Feb 16 2020.  MDPI.  https://www.mdpi.com/1420-3049/25/7/1618

[32] N Singh, A Bharara. S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA and in silico study.  Oct 2020.  13 (10).  100814.  https://www.sciencedirect.com/science/article/pii/S1936523320303065?via%3Dihub

[33] C Huber.  Africa is starkly unvaccinated. Jan 15 2023.  https://colleenhuber.substack.com/p/africa-is-starkly-unvaccinated