Cancer patients have come into our clinic after trying fenbendazole to shrink tumors, with disappointment that it had not worked and upheaval in their liver labs.
Thanks Dr Huber. Wondering if you know the dosage/duration of the fenbendazole treatment that resulted in the liver enzymes your show in your table? First I've seen numbers for that though to be honest I haven't looked very hard.
My understanding is that the patient was taking 1 or 2 caps per day, uncertain of dose, for some weeks and for most days, until we implored stopping it. This was from an online vendor. Then the liver labs started moving toward normal. The pancreatic mass had already stabilized with our clinic's treatments prior to the patient choosing to add fenbendazole, and as with our other pancreatic cancer patients, there is evidence of this patient's stability and remission, but not yet certainty. (Radiologists are notorious for hedging their bets - not pronouncing either confirmed resolution of cancerous process or otherwise, in cases of stable imaging). Hence, there is a holding pattern of wait-and-see when patients arrive to this point.
What metrics were used to conclude that there was liver damage? Ben Fen raises valid and important points here. When i was dealing with the Multiple Myeloma patient we were doing metabolic bone scans (PET studies). Lytic lesions (the holes left in the bones where the cancer was) as indicative of metabolic activity consistent with cancer.
In his case lesions were actually going away and it appeared that new ones were forming,
In actuality the activity is related to bone remineralization/remodeling/regrowth in the previously cancer-filled holes as Ben Fen so eloquently pointed out.
However it was considered evidence at the time by the oncologist that the Fenbendazole was not working even though the patient was declared in 100 percent full remission shortly after that. I might add that two years later that remission has held.
My point is that traditional metrics can be easily misinterpreted as oncologists are not use to protocols that actually work.
No other Rx or OTC drugs were taken by that patient, only nutrients. But don't rely only on a report from one patient. Please see the studies I linked to in the endnotes, which show liver toxicity, which, again, is very well known with this class of anti-helminthic drugs. The human version of fenbendazole, which is mebendazole, trashes the liver so fast that the course is only two days, because it is not tolerated for longer.
There are several dozen natural substances that work more effectively against cancer than fenbendazole. See https://natonco.org.
Yes, ivermectin has a vastly better profile. It is very early in use against cancer, but is showing very good effect so far, and does not have the toxic profile of the benzimidazole anti-helminthics. The safety studies for ivermectin went all the way down to toddler age without ill effect, and none of the pregnancies were lost. Four billion doses of ivermectin had been given around the world prior to the COVID years. Yes, it is vastly better in every way that I have seen than the benzimidazole anti-helminthics.
thank you so much, can high basophil. granulocytes indicate covid 19 infection? mine are 1.3 now, they were 1.1 in 2023...and before covid 19 always 0!....i have pain in my left shoulder for months
"Why not consider those treatments primarily that do not have a toxic profile, before considering ones that have little confirmed effect and are known to have a concerning toxic profile?"
Thank you for getting to the most important point of the article. It is possible to defeat cancer with only non-toxic treatments. So let's look into those thoroughly, before considering the anti-helminthics that are so harsh on the liver. To hear the fenben vendors tell it, the liver can take a trashing, and that seems worth it to them. However, it is not worth it. What kills chemo patients is often liver injury. Liver function is essential to being able to survive chemo and to survive cancer, assuming one is challenged with both.
As I say, we have been helping cancer patients achieve and sustain remission with only natural treatments. Some chose to also have chemotherapy and / or radiation and / or surgery.
Many thanks for addressing this. I have commented for some time in substacks that fenbendazole is neuro-toxic and I considered that as there are non-pharma approaches there was no point in using it.
I have a diagnosis of cancer which was a melanoma in my parotid gland and received immuno-therapy in 2020 until I realised in Sept that year that I had sodium nitrite (E250) poisoning via bacon I ate. This has been known to be neuro-toxic for over 100 years and the compound nitrosamines which is highly toxic for at least 40 years and said to be carcinogenic. The useless NHS doctors never asked about my diet.
Thank you for pointing out this extremely concerning effect of the benzimidazole anti-helminthic mechanism, namely its interference with both formation and function of microtubules, extending to the brain and nervous system, as you point out.
The use of this weak chemotherapy drug, dosed by its enthusiasts at 444 mg 1-2x/day caused new damage in the body that the fenben vendors seem to want to sweep away, as if the liver and brain were expendable.
There are many known ways to attack cancer with natural substances, https:NatOnco.org, and those have shown strong effect over decades https://NatureWorksBest.com.
Buyer beware of fenbendazole, a weak OTC chemotherapy, with its adverse effects on multiple organs.
Yes, no one really apprexiates the author with 17 year experience in cancer treatment honest scientific opinion, but instead talk around the subject. There is a huge diference with what wants to hear and what she is telling us. It is important to focus on liver enzymes and when and how the enzymes start to show elevation. Will it be when fenben is used on a daily basis for a certain amount.of days etc..
https://fenbendazole.substack.com addressed the elevated liver enzymes recently. Here is that presentation: Does Fenbendazole Cause Liver Damage?
Some have expressed concern that fenbendazole has been linked to liver injury. There is a report documenting the effect of fenbendazole on liver function as measured by the enzymes aspartate transaminase (AST) and alanine aminotransferase (ALT). A search using Google of “fenbendazole and cancer” returns this case report as the first result: Teppei Yamaguchi, Junichi Shimizu, Yuko Oya, Yoshitsugu Horio, Toyoaki Hida. Drug-Induced Liver Injury in a Patient with Nonsmall Cell Lung Cancer after the Self-Administration of Fenbendazole Based on Social Media Information. Case Rep Oncol 1 September 2021; 14 (2): 886–891. https://doi.org/10.1159/000516276
Elevated liver enzymes may actually be a good sign for a cancer patient taking fenbendazole. Those liver enzyme (AST, ALT) values may spike for one or two months as the liver is stressed by the influx of dead cancer cells as it filters and processes the cellular debris from those dead cancer cells. AST and ALT increasing is a sign of hepatic stress (work), not necessarily disease, in the context of fenbendazole use. These liver enzymes usually normalize after the cancer is eradicated by fenbendazole.
FYI, liver enzymes will also fluctuate with other noncancerous sicknesses/recoveries as dead cellular debris enters the bloodstream and is processed by the liver for removal. This is part of a normal physiological process. Temporary liver enzyme fluctuation should be expected to occur as a matter of course when using fenbendazole as fenbendazole kills the cancer cells.
I forgot to tell you that Methylene Blue also eradicates these things.
In a book I was just reading it says “The life cycle of parasites, bacteria, fungi and viruses are all in jeopardy when in the presence of Methylene Blue. And when used in combination with light therapy, Methylene Blue exerts even greater anti microbial effects against bacteria, like E. coli and others, including drug resistant strains, against fungi like Candida, and also against many common viruses, including Zika, West Nile, Ebola, Hepatitis and HIV.”
I take it every day now along with the anti parasitics and other things!
Thanks for the explanation. The more I learn about the liver this seems to make sense. Everything has to filter through the liver, hormones, etc. all the chemicals we have been in contact with over the years. It still functions, but slows down as we age because we don’t get rid of all that junk. Also, if the lymphatic System is clogged as we will have double the back up.
It’s imperative to clean up, detox and give the body extra support if your going to take anything new. Give the body what it needs during this time.
Just thinking as a lay person that likes to read and understand how things work, I’m not a Dr.
I’ve shown you enough of these ALT/AST panels vacillating and returning to normal after monkey hammering tumors of all sorts into
Oblivion
I’ll let you inform this nice lady.
You have the bedside manner of a nice Dr
I’m a hard bastard and don’t won’t to have to blow this article outta the water with massive successes that include FBZ as one of the components coupled with liver panels where >80% of the people see no
Raised ast/alt levels
Then I’ve shown you elevated panels in less than 20% of the people that absolutely clear their soft tissue Cs
Many experimental and clinical investigations have confirmed the hepatoprotective effect of extracts and their active components. Milk thistle (Silybum marianum) has many benefits, including antioxidant, anti-inflammatory, liver protection, and neuroprotective effects. A marked reduction in the plasma levels of liver enzymes such as ALT, AST, and ALP by silymarin has been repeatedly reported.
Milk thistle, green tea, and cinnamon are used in this study. Milk thistle was #1
Makes sense, i almost got a fright here.. i am only using fenben 3 days a month. I do have liver problems and gp's don't really discuss the functionality of the l iver but only wants to promote statins by doing so...or fatty liver.
You might already know this but eating more choline (best sources are egg yolks and liver) and/or taking a choline supplement is a huge benefit for the liver. I take phosphatidyl choline as I have a genetic SNP that makes me require extra choline. Many people are deficient.
Eating sprouts helps only a tiny bit because they contain only a fraction of the choline you need. 100 grams of sprouts (a large serving) contains 15 mg of choline while an egg yolk contains 147 mg.
But if that's too complicated, just err on the side of eating extra.
Chris Masterjohn (my favorite nutrition researcher) recommends the average person get 550 mg of choline per day but those with genetically higher requirements may need up to 1000 mg. I hope that helps.
Can you test for choline deficiency? I am fond of eggs, not so much liver, although ocassionally i do enjoy some liver. Will chicken liver also be good? Or will it be just red meat liver?
Unlike vitamin D and other vitamins, you can't test for choline with a blood test. The way choline deficiency is usually discovered is through elevated liver enzymes and fatty liver disease. Some people genetically need more choline than others. Here's a medical study that explains more: https://pubmed.ncbi.nlm.nih.gov/22134222/
Here's a quote from the study: "Humans eating low-choline diets develop fatty liver and liver damage. This dietary requirement for choline is modulated by estrogen and by single-nucleotide polymorphisms in specific genes of choline and folate metabolism. The spectrum of choline's effects on liver range from steatosis to development of hepatocarcinomas, and several mechanisms for these effects have been identified. They include abnormal phospholipid synthesis, defects in lipoprotein secretion, oxidative damage caused by mitochondrial dysfunction, and endoplasmic reticulum stress. Furthermore, the hepatic steatosis phenotype can be characterized more fully via metabolomic signatures and is influenced by the gut microbiome. Importantly, the intricate connection between liver function, one-carbon metabolism, and energy metabolism is just beginning to be elucidated."
You can get choline from chicken liver, beef liver, and lamb liver. I make sure to eat 4 eggs yolks every day as well as taking the choline supplement as I recover my health. You are right that choline is also found in soy lecithin. I bought a bottle and I add it sauces but it's a little strange and my family was less than thrilled last time I tried to sneak it in a recipe. I'm better off adding egg yolks to sauces.
I love my eggs, but ended up having less than normal, because my husband had a heart attack, AND 10 years later triple bypass after taking statins for years, and he still believes msm that eggs are poison for cholestrol. Maybe i should just pop raw eggs in a smoothy every day, egg white intact. Eggs are poison and statins are the magic treatment. I have high cholestrol but luckily i do not take statins, i am worse off when i tried to years ago. Swollen ankles like a michelin man in 2 weeks. My cholestrol is higher than my husband's. Only difference perhaps is he has a stressful job. Every time i visited my gp (don't visit them after these recent public lies though), he used to say i am going to die (fear nonsense again) ifni don'tbuse the strongest statin, onto whichni sad (i don't want your statins of medicine (because if i do, i will have to take water pills and develop high blood pressure eventually) ," i am only interested in your diagnosis", which made him furious. So, i have my fair share in distrusting mainstream drs.. sorry, they have to go back to school and learn about prevention as well, but then it will kill their symptom treating money making machine.
Thank you! I have learned 1000 % more from you than from my internist who only said "ma'am, stay away from purine and fat". After being scared into coming for regular check-ups after being initially diagnosed with black liver hemangiomas and cysts, they ended up hooking you in with 6 months visits to the radiology dept and an "interpretation" visit scheduled at your internist, telling you nada about techniques like choline... what a waste of time. I was just feeding them money to keep up their lifestyles and wash each other's backs. What a legitimate joke. And i am the sucker. And driving 1000 km to discuss the radiology report tellkng me again to stay away from red meat (like gout), having a faulty/battling liver end up having gout, and since they only treat symptoms and not cause, it is a never ending cycle.
The truly surprising thing is that medical schools teach almost nothing about human nutrition--only how to prescribe drugs! The sad thing is that 100 years ago, most doctors were integrative but Rockefeller bought out all the medical schools and began controlling their curriculum to sell pharmaceuticals. But one thing that makes me so excited is that we have access to ancient healing strategies like nutrition, fasting, and ketosis. I was able to reverse my type 2 diabetes, heal migraines of 25 years, and put an autoimmune disease into remission just by practicing intermittent fasting, eating more protein including red meat, cutting seed oils and reducing carbs, and taking some key supplements such as choline, B vitamins, and cod liver oil.
One more thing: I can't remember if I already said this or not but you also need the amino acid glycine for liver health. You should be able to buy it in powder form and add it to tea or coffee (or anything). It's slightly sweet. It also helps skin.
Time and time again i tried tcm, for e.g. panaxea oool blue, and i end up with liver pains, same with berberine. It is kind of hard to get single products in south africa, so i could only get hold of berberine complex (chromium, milk thistle and berberin). Always ending up not to know which of these supplements are harming my liver/making my liver battle. These supplements also cost us a fortune in our country, since most are imported. I ended up being able to purchase grounded milk thistle, but don't know how much and how often.
Many experimental and clinical investigations have confirmed the hepatoprotective effect of extracts and their active components. Milk thistle (Silybum marianum) has many benefits, including antioxidant, anti-inflammatory, liver protection, and neuroprotective effects. A marked reduction in the plasma levels of liver enzymes such as ALT, AST, and ALP by silymarin has been repeatedly reported.
Milk thistle, green tea and cinnamon were used in this study... Milk thistle was #1
You are overstating liver damage caused by fenbendazole that is actually more common as a problem in animals and is a rare side effect in humans. I do agree that that no magic bullet exists for any disease and a holisitc approach is called for. As a care giver thanks to Fenbendazole I was able to bring back a stage 3 Multiple Myeloma patient who correctly rejected a toxic chemo therapy/useless stem cell approach (harvesting his own stem cells) who was given a grim prognosis of 2 months to live to100 percent full remission in seven months.
However, it called for much more than just Fenbendazole. I had to make sure that his glucose intake was eliminated ie - he enjoyed a few bottles of wine ever day that i convinecd him needed to be eliminated and substituted this with canaboid oil that also has some anticancer properties and had a way of relieving his anxiety.
Substituting sugar with allulose was crucial. supplementing vitamins etc and the list goes on.
i am a fan of the Warburg effect and little doubt in my mind that cancer is a metabolic disorder.
Hence depriving hypoxic cancer cells of glucose and glutamite that resort to mitochondria relying on fermentation to produce energy via lactate instead of oxidative phosphorylation generating AtP is crucial.
Are you going to tell us next that these Dr's at Stanford that studied these three patients who were at death's door and saved by Fenbendazole are promoting "street drugs"?
ALLULOSE - also known as D-allulose or D-psicose, is a sugar that occurs naturally in some foods, but it can also be made from fructose as a commercial food product using enzymes to convert fructose into allulose.
Allulose is classified as a rare sugar because it is naturally present in only a few foods - wheat, figs, jackfruit, maple syrup and molasses. Like glucose and fructose, allulose is a monosaccharide, or single sugar. In contrast, table sugar, also known as sucrose, is a disaccharide made of glucose and fructose joined together. Allulose has the same chemical formula as fructose but is arranged differently. This difference in structure prevents your body from processing allulose the way it processes fructose. Although around 70% of the consumed allulose is absorbed into the blood through the digestive tract, allulose leaves the body via urine, without being used as fuel. Allulose also provides only 0.2–0.4 calories per gram, or about 1/10 the calories of table sugar. Allulose does not raise blood sugar or insulin levels.
Research suggests that allulose has anti-inflammatory properties and may help prevent obesity, reduce the risk of chronic disease and is a powerful tool for managing diabetes. Several animal studies have found that it may lower blood sugar, increase insulin sensitivity, and decrease the risk of type 2 diabetes by protecting the insulin-producing beta cells of the pancreas. Research also suggests that allulose may have beneficial effects on blood sugar regulation in humans.
Furthermore, research suggests that allulose may help increase the loss of fat, including unhealthy belly fat, which is also known as visceral fat. This type of fat is strongly linked to heart disease and some other health conditions. A study of healthy adults found that taking 5 g of allulose before a meal appeared to lead to improved energy metabolism after they ate, which could help manage body weight. In addition to preventing weight gain, allulose seems to reduce fat storage in the liver. Hepatic steatosis, more commonly known as fatty liver, is strongly linked to insulin resistance and type 2 diabetes. In one study, mice with leptin deficiency and obesity were given allulose and showed lower total fat mass and liver fat after 15 weeks. These changes occurred without exercise or restrictive diets.
While it promotes fat loss in the liver and body, allulose may also protect against muscle loss. In the same study of mice with obesity, allulose significantly decreased liver and belly fat and appeared to prevent the loss of lean mass.
Allulose has been added to the list of foods generally recognized as safe by the Food and Drug Administration.
The same mechanisimns of denying the fermenting cells glucose apply to cancer as they apply to diabetes 2.
An interesting sugar, but I believe glycine does most if not all of that, and also does more - lots of health benefits. I use around 10 g per day.
1) Skin Health
Glycine (through the consumption of collagen) significantly improved skin elasticity in elderly women and improved skin moisture and water loss [4, 5].
Collagen peptide, which contains a lot of glycine, suppressed UV-B induced skin damage and photoaging [6].
Women taking 2.5g of collagen peptide for 4 weeks significantly reduced eye wrinkles by 20%, with positive effects lasting after the study ended [7].
At 8 weeks, collagen significantly improved skin content of procollagen type I by 65%, and elastin by 18%.
Diabetic Ulcers
Glycine nearly doubles the speed at which skin ulcers heal in 89 diabetic patients across 23 long term care facilities [8].
Glycine enhanced wound healing in diabetic animal models as well [9].
Glycine in combination with l-cysteine and dl-threonine topically applied to leg ulcerations significantly improved the degree of wound healing and decreased pain [10].
Glycine’s best evidence of benefit comes for its effect on diabetic leg ulcers. Nevertheless, additional research is required before it will be considered sufficient to support a medical claim.
2) Mental Illnesses
Schizophrenia
Glycine supplementation significantly reduced symptoms of schizophrenia [11].
In treatment-resistant schizophrenia glycine improved cognitive and depressive symptoms (dosed at 0.8g/kg).
The group who made the most improvement were also the most deficient in glycine [12].
Glycine helps in chronic schizophrenia by increasing NMDA-receptor-mediated neurotransmission [13].
This effect on NMDA-receptor-mediated neurotransmission allows for glycine to work synergistically with schizophrenia medication [11].
OCD
Glycine supplementation has been shown in one instance over the course of 5 years to significantly reduce symptoms of OCD and body dysmorphic disorder [14].
Glycine has positive results when used in the treatment of obsessive-compulsive disorder in adults [15].
Depression
Depression is associated with lower levels of blood glycine, as well as high levels of taurine [16].
Glycine is most likely to be beneficial for people with schizophrenia and could be beneficial for people with other types of mental illness. Additional human trials will be required to determine glycine’s potential role in mental health.
3) Brain Health
Small amounts of glycine have been shown to dilate the microvessels in the brain by up to 250% [17, 18].
In rats with alcohol poisoning, glycine was able to reduce the accumulation of cholesterol, free fatty acids, and triglycerides in blood circulation, liver, and brain. Ultimately, this decreases swelling in the brain [19].
A shortage of glycine in the brain can negatively influence the brain neurochemistry, synthesis of collagen, RNA/DNA, porphyrins, and other important metabolites [20].
Stroke
In ischemic stroke patients, taking glycine 1 – 2g/day normalized autoantibodies, reduced glutamate and aspartate levels, increased GABA concentrations, and reduces lipid peroxidation [21].
Those who consume regularly low doses of glycine actually reduce damage in future strokes [21].
The glycine treatment at the dose of 1 – 2g/day was accompanied by a tendency to a decreased risk of dying over 30-days [21].
500mg/kg glycine combined with 500mg/kg Piracetam improved cognitive impairments and promoted recovery in the prefrontal cortex in animals with a stroke [22].
There is relatively good evidence that glycine could play a role in stroke prevention and recovery; larger, more robust, and more specific human trials will be required.
Insufficient Evidence For
The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of glycine supplements for any of the below-listed uses. Remember to speak with a doctor before taking glycine supplements, and never use them in place of something your doctor recommends or prescribes.
4) Sleep and Fatigue
Taking glycine before sleep improves sleep quality and sleep efficacy by shortening the time to fall asleep while increasing restorative, slow-wave deep sleep [23].
After taking glycine for sleep, the following day subjects had lessened daytime sleepiness and improved performance of memory recognition tasks [23].
Glycine helps improve REM sleep and decrease non-REM sleep [24].
3g Glycine given to volunteers before sleeping resulted in improvements in fatigue, ‘liveliness and peppiness,’ and ‘clear-headedness’ [25].
Glycine appears to improve daytime sleepiness and fatigue induced by sleep deprivation [26].
Glycine affects certain neuropeptides in the SCN (suprachiasmatic nucleus) in the region in the hippocampus which regulate the circadian rhythm [26].
Specifically, glycine increases VIP, which is critical to the circadian rhythm.
This effect on the SCN indirectly contributes to reducing sleepiness and fatigue induced by sleep restriction [26].
In clinical studies, glycine supplementation reduced daytime sleepiness and fatigue and made people feel more lively and clear-headed after sleep deprivation.
5) Gut Health and Ulcers
Glycine dramatically increased the tolerability of Aspirin in the upper GI tract of 20 healthy human volunteers [27].
Glycine inhibits stomach acid secretion and protects against chemical and stress-induced ulcers [28].
Glycine prevents chemically induced colitis in animal models [29].
Glycine prevents alcohol-induced stomach lesions (ex. ulcers) when used as a pretreatment in animal models [30].
In small intestine grafts, glycine improves smooth muscle dysfunction after transplantation as well as reduces inflammation [31].
Glycine, but not L-arginine, is able to maintain intestinal wall integrity and mucosa in cancer treatment irradiation in animal models [32].
Glycine has protective effects against oxidative stress in intestinal cells in test tubes [33].
Glycine could potentially help prevent the formation of ulcers in response to stress or harmful chemicals, but human studies have been very limited.
6) Metabolic Disorders
5g glycine taken in the morning increased total insulin response in 12 healthy first-degree relatives of Type 2 diabetes patients [34].
Glycine is believed to help with diabetes and metabolic disorders [2].
Glycine intake decreases free fatty acids in blood, fat tissue cell size, and blood pressure in sucrose-fed rats [35].
Glycine reduces glycated hemoglobin (A1C), a risk factor associated with poor blood glucose management in patients with type 2 diabetes. The dose was 5g/d [36].
Glycine stimulates the secretion of a gut hormone (glucagon) that helps insulin to remove glucose from circulation [37].
Glycine helps patients with oxidative stress in the development of metabolic syndrome [38].
Glycine increases adiponectin, which may trigger weight loss in obese people, but this effect has only been observed in a cell study [39].
Glycine is considered important for metabolic health, but much of the research on this topic is limited to animals and cells.
7) Glucose Balance & Diabetes
Diabetic patients have 26% lower blood glycine levels than “normal” population [40].
Glycine helped 8 older, male HIV patients restore insulin sensitivity [41].
Glutathione synthesis was restored in patients with uncontrolled diabetes and hyperglycemia with glycine (+cysteine) added to their diet [42].
Glycine helps with lipid profiles in insulin-resistant patients (but not insulin resistance).
Glycine can help with positive glucose management by stimulating the production of Glucagon, a hormone which helps potentiate the action of insulin [37].
These early studies are promising, but larger and more robust human trials are needed.
People with diabetes appear to have lower blood glycine than the average, and glycine supplementation improved insulin sensitivity and glutathione synthesis in diabetic patients.
8) Heart Health
Glycine lowered systolic blood pressure in 60 patients with metabolic syndrome [38, 41].
In heart attack conditions (Post-ischaemic reperfusion) glycine prevented the death of heart muscle cells by inhibiting mitochondrial permeability in rats [43].
Glycine depletion within cells during a heart attack (hypoxia/reoxygenation) may make heart cells more vulnerable to cell death [43].
Glycine lowered blood pressure in patients with metabolic syndrome; glycine’s role in heart health has otherwise not yet been studied in humans.
9) Joint, Bone, and Muscle Strength
Glycine improved body composition and muscle strength in 8 older men with HIV [41].
Glycine protected against (peptidoglycan polysaccharide-induced) arthritis in animal studies [28].
Glycine combined with green tea benefits tendon recovery processes after tendinitis by better collagen bundling organization [44].
Glycine can potentially help in menopause because of its estrogen-like bone protective effects [45].
Glycine played a role in maintaining the health of mice suffering from osteoarthritis [45].
Glycine is believed to be important for joint, bone, and tissue strength. High-quality human research into this potential benefit is lacking.
While glycine is an important nutrient with potential health benefits, it is not directly comparable to Allulose in terms of its effects on cancer cell metabolism or the Warburg effect. . Both glycine and allulose may have their respective places in nutrition and therapeutics, but they are not interchangeable, and their roles should not be conflated.
Ive tried pure encapsulation glycine because I get a practitioner discount and bulk supplements glycine. I couldn’t tell the difference so stuck with bulk supplements.
Thank you for this great info! I’m 60, take a high quality collagen (Designs for Health) which has three different types of collagen in it. A serving has 12.5g collagen. If people take this, do they also need to take amino acids? Sometimes I’ll take amino acids before strength training. Not sure if this is too much or if they work differently?
You always have such helpful information. I appreciate the time and energy that you put in. Many of us are people that completely trusted our beloved doctors. We are now lost and scrambling for true information. I so need an uncaptured doctor but I can't seem to find any. I feel so lost because no one believes me about the shots, my heart feels broken. Anyway I appreciate you!
Sid - This is fascinating! Do you have more info on allulose and/or any links to studies or articles? I would love this for myself and to pass along to a couple of other people. I believe you need a substack of your own:)
Why 6 grams? Why not 5 or 10 or 30 grams? 6 grams sounds like you're measuring it out which is not at all necessary. It's safe up to (and probably beyond) 60 grams.
I throw it on everything, burgers, kimchi, cottage cheese, in coffee. Don't know how much but around 15 grams with no prob. I also believe that the same dose everyday is not natural.
More of a good thing is usually better, despite what people say, although one must always be reasonable. Don't be afraid to experiment - nutrients are not drugs - they won't kill you. Go wild.
Can we stop posting references of studies with conflicts of interest from big pharma? And more details on elevated liver enzymes would help, like were they taking more fenben than they should be taking?
My great-grandmother told me that laughter is the best medicine and she lived to 92 after being bitten by a rattlesnake as a young girl. She was engaged to the founder of the Dr. Pepper Co. but broke her engagement and ran off with a railroad man. There went my chance to be a big soda pop typhoon.
Acetaminophen i can be nasty stuff. When my son was four, he had a cold that (unbeknownst to me) progressed to pneumonia. I was giving him an over-the-counter pediatric cough/cold medication that contained acetaminophen. Long story short, he was life-flighted to an urban pediatric hospital, and after a couple of days where they did a liver biopsy and were talking possible transplant, his liver, which had been 30% dead according to the liver specialist, staged a miraculous recovery in record time. The specialist later calculated that he had been getting a 1/3 dose of acetaminophen for his body weight but since he was weakened from the pneumonia, it drastically affected his liver. This is the same thing that happens to alcoholics.
Fast thinking saved him! Acetaminophen is in many different OTC remedies. If we lived in a just workd it would have bewn removed from the market for safety and redundancy issues many years ago.
Actually, his pediatrician did extra testing and discovered unusual liver numbers, at which point he was life-flighted. That was the fast thinking for which I'll be forever grateful. Once he was hospitalized, of course, he quit getting the OTC crap. Before they figured out what had caused the problem, the specialists were asking me if he could've gotten into any wild mushrooms (in Utah! In January!) or the like.
I did have a lawyer look into some sort of legal action, not for ourselves, but because I was appalled such a dangerous substance is getting popped like candy by the general public thinking it's safe. As I now know, Pharma has ways of covering their ass.
I hope Joe Rogan has you on his podcast soon. I’m sure you would have a good discussion and many people would benefit. (But if you do, I hope you know of docs who practice similarly to you around the US / globe, so you aren’t slammed with requests.)
Does anyone on this substack know anything about natural treatment for recurrent UTI?I have had info from a friend regarding a product call UQORA. I have researched it. The gist of their product is to prevent bacteria clinging to the wall of the bladder. Would appreciate anyone’s referral for info. Thank you in advance.
If it's acute then the best thing is to alkalise the urine. Drinking a large glass of water with a teaspoon of potassium citrate or plain old sodium bicarbonate stirred in will help.
UroFem D Mannose. I know several people, including my mum who have had excellent results preventing recurrent uti. I don't know anything of other brands.
I use methylene blue which was the standard of care for UTIs before antibiotics were invented. I bought it on Amazon and put one dropper into a glass of water. If you take it straight it will stain your teeth and tongue blue but not if you dilute it.
Honestly, I have not used it and I just found it so I really don't know. She's really tough about taking supplements and eating well but if it was me I would probably try it. Her biggest issue is she's become antibiotic resistant.
Dr. Gerson found his cancer patients were dying, not of the cancer rather due to hepatotoxicity. He added coffee enemas to the protocol, and his patients stopped dying.
Thanks so much for writing this. I keep seeing comments and advertisements for fenbendazole and wondered where the studies were for how safe and effective it is. Also thanks for the link to the natural treatment website.
42% of newly diagnosed cancers in the US are potentially avoidable. These simple adjuncts such as lifestyle changes, supplements and drugs can help you manage and "starve" cancer:
1. Low-carb, high-fat, ketogenic diet plus time-restricted eating (intermittent fasting).
2. Exercise, stress reduction, and obtaining quality sleep.
3. Vitamin D3: 20,000-50,000 IU daily1
4. Melatonin: start 1 mg and increase to 20-30 mg nightly (extended/slow release)
5. Green Tea catechin, epigallocatechin-3-gallate (EGCG): 500-1000 mg/day
“Heart disease, cancer, medical errors and abuse, accidents, stroke, Alzheimer’s, and diabetes are the main causes of death. These are all preventable. The cure is ‘studying’.”
The cures for cancer (or any other disease, even if rare), could be found in days, if already in use: all we need is the physicians, hospitals, ministries of health, patients or their survivors, to upload the clinical records of what they already used to treat their patients to a standardized database which applies real-time multi-linear regression:
• disease stage when treatment begun
• not the prescribed but real life dose/kg and uptake frequency of medicines/food/nutrients/nutraceuticals
• changes in relevant lifestyle data (exercise, sleeping, etc.)
• disease evolution
• survival phases
Also, the platform will help discard current treatments which actually harm or kill patients (e.g. remdesivir, injections).
There could be prizes for the most effective treatments, reproduced by other doctors.
There should be a procedure to eliminate or reduce fake data, for example, to check the uploaded photos of documents proving the data.
There should be a medical social network for collaboration and dissemination.
We could have done it with COVID treatments! We should prepare the platform for the next PLANNEDemics.
How about crowdfunding?
Big mammoth in the room: why hasn’t any government done this? !!!
You can and should do far more melatonin than that - I take 120 mg or 180 mg per night. it's not a soporific, it's an antioxidant, many times better than vitamin C because it's metabolites and metabolites of metabolites continue to scavenge and neutralize free radicals.
Amazon has 60 mg caps of melatonin. For sleep, 0.3 mg may be best. There is no effect of high-dose melatonin on your body's natural production of melatonin. That's not a concern, it does not interfere short- or long-term.
That article mentions near infrared wavelengths stimulating melatonin in cells. Maybe so, but I had a friend who did mice research on cancer at Mass General and the one cohort of mice that had infrared therapy all died. No need to bake under red lights - just dose up with melatonin.
From that linked article: "“I'm going to give you a very specific example,” Reiter says. “Here's a local physician, Dr. Richard Neil, whom I have known for a number of years. When COVID-19 became common, he called me, we discussed it, he started giving 1 mg per kilogram of body weight (once a day) for about five days, at the time of diagnosis. He has now treated more than 2,000 patients, very successfully, with melatonin."
There are apparently many cures for covid but the doctors don't know any of them.
If you had a patient come in with toxicity from acetaminophen, what's the first question? "What dosage was the patient taking?" of course.
This article seems to highlight on instances where patients were possibly taking dosages outside the typical "Tippens Protocol" recommendation of 222mg Fenben 3 days on, 4 days off.
Regarding the patient bloodwork prominently posted in this article...Dr Huber, you note in another comment: "My understanding is that the patient was taking 1 or 2 caps per day, uncertain of dose, for some weeks and for most days, until we implored stopping it. This was from an online vendor. Then the liver labs started moving toward normal." So...the patient dosage was unknown.
When I look online at such as Amazon, I see they sell both 222mg and 444mg Fenben capsules...I really don't know why they sell the 444mg, when it's double the typical protocol.
In other words, the patient was taking perhaps 222mg most days...or possibly 444mg depending on the caps...or possibly (when taking 2 caps) 444mg or 888mg ... in other words, it's unknown the dosage the patient was taking, and taking that unknown on contiguous days. In other words, the patient could've been taking 1-4X or more possibly the recommended dosage/day. And if taking a higher dosage every single day without the typical 3 days on, 4 days off, it seems unsurprising that toxicity could occur.
Or take #3 referenced link from NIH, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255718/ - when a person digs in, it says: "She stated her fenbendazole schedule consisted of 1 g/day PO for 3 days, followed by 4 days off, and this schedule had been maintained for approximately 1 month from early July until her August visit. We stopped fenbendazole administration immediately, and her liver function parameters gradually improved."
In other words, this patient was taking the standard 3 days on, 4 days off protocol...but at 1g/day, she was taking 4.5X the recommended 222mg dosage. Correct me if I'm off base, but taking 4.5X recommended dosage of most anything can have adverse effects, correct? Please try taking 4.5X of acetaminophen ... no, just kidding, please don't!!!! But therefore, should we demonize acetaminophen because it's possible to take damaging dosages.
I'd have found this article much higher on the validity scale if I didn't have to dig in and locate these hidden facts, that should've been prominently noted as "when taking ANYTHING don't mess around with higher dosages/frequency than recommended." Disclaimer: I've been taking the standard Fenben protocol most weeks for the last two years or so, some weeks off here and there. I had a right radical nephrectomy for renal cell carcinoma over 5.5yrs ago, and I added Fenben as part of my protocol to help prevent recurrence. I also daily take NAC, SAM-e, C, garlic, etc ... items that happen to be liver supportive among with other other benefits.
Thanks Dr Huber. Wondering if you know the dosage/duration of the fenbendazole treatment that resulted in the liver enzymes your show in your table? First I've seen numbers for that though to be honest I haven't looked very hard.
My understanding is that the patient was taking 1 or 2 caps per day, uncertain of dose, for some weeks and for most days, until we implored stopping it. This was from an online vendor. Then the liver labs started moving toward normal. The pancreatic mass had already stabilized with our clinic's treatments prior to the patient choosing to add fenbendazole, and as with our other pancreatic cancer patients, there is evidence of this patient's stability and remission, but not yet certainty. (Radiologists are notorious for hedging their bets - not pronouncing either confirmed resolution of cancerous process or otherwise, in cases of stable imaging). Hence, there is a holding pattern of wait-and-see when patients arrive to this point.
What metrics were used to conclude that there was liver damage? Ben Fen raises valid and important points here. When i was dealing with the Multiple Myeloma patient we were doing metabolic bone scans (PET studies). Lytic lesions (the holes left in the bones where the cancer was) as indicative of metabolic activity consistent with cancer.
In his case lesions were actually going away and it appeared that new ones were forming,
In actuality the activity is related to bone remineralization/remodeling/regrowth in the previously cancer-filled holes as Ben Fen so eloquently pointed out.
However it was considered evidence at the time by the oncologist that the Fenbendazole was not working even though the patient was declared in 100 percent full remission shortly after that. I might add that two years later that remission has held.
My point is that traditional metrics can be easily misinterpreted as oncologists are not use to protocols that actually work.
people are using Tudca to prevent liver issues. I use it ... not this particular product though. https://bodybio.com/blogs/blog/what-is-tudca
1. We are not sure of the dose and quality of the drug, right?
2. Were those patients only taking fenbendazole prior to those analysis? Could there be other confounding drugs?
Thank you, we need to clarify this
No other Rx or OTC drugs were taken by that patient, only nutrients. But don't rely only on a report from one patient. Please see the studies I linked to in the endnotes, which show liver toxicity, which, again, is very well known with this class of anti-helminthic drugs. The human version of fenbendazole, which is mebendazole, trashes the liver so fast that the course is only two days, because it is not tolerated for longer.
There are several dozen natural substances that work more effectively against cancer than fenbendazole. See https://natonco.org.
Thank you! Have you also tried ivermectin? some are reporting good results.
Yes, ivermectin has a vastly better profile. It is very early in use against cancer, but is showing very good effect so far, and does not have the toxic profile of the benzimidazole anti-helminthics. The safety studies for ivermectin went all the way down to toddler age without ill effect, and none of the pregnancies were lost. Four billion doses of ivermectin had been given around the world prior to the COVID years. Yes, it is vastly better in every way that I have seen than the benzimidazole anti-helminthics.
https://colleenhuber.substack.com/p/ivermectin-is-safe-and-effective
thank you so much, can high basophil. granulocytes indicate covid 19 infection? mine are 1.3 now, they were 1.1 in 2023...and before covid 19 always 0!....i have pain in my left shoulder for months
Search for "anti-cancer" and for the scientific references:
https://scientificprogress.substack.com/p/the-super-drug
"Why not consider those treatments primarily that do not have a toxic profile, before considering ones that have little confirmed effect and are known to have a concerning toxic profile?"
Can you list those, please?
Thank you for getting to the most important point of the article. It is possible to defeat cancer with only non-toxic treatments. So let's look into those thoroughly, before considering the anti-helminthics that are so harsh on the liver. To hear the fenben vendors tell it, the liver can take a trashing, and that seems worth it to them. However, it is not worth it. What kills chemo patients is often liver injury. Liver function is essential to being able to survive chemo and to survive cancer, assuming one is challenged with both.
Anyway, to answer your question, the source I cited in the article for non-toxic natural substances with anti-cancer effect is https://natonco.org, which cites over 700 peer-reviewed studiesr. I wrote about our own clinic's experiences here: https://natureworksbest.com/wp-content/uploads/2018/01/2017-Cancer-treatment-paper.2017.12.30.pdf
As I say, we have been helping cancer patients achieve and sustain remission with only natural treatments. Some chose to also have chemotherapy and / or radiation and / or surgery.
Do you have a published protocol that you consider safe and effective so that those of us unable to access medical help can self-medicate?
Many thanks for addressing this. I have commented for some time in substacks that fenbendazole is neuro-toxic and I considered that as there are non-pharma approaches there was no point in using it.
I have a diagnosis of cancer which was a melanoma in my parotid gland and received immuno-therapy in 2020 until I realised in Sept that year that I had sodium nitrite (E250) poisoning via bacon I ate. This has been known to be neuro-toxic for over 100 years and the compound nitrosamines which is highly toxic for at least 40 years and said to be carcinogenic. The useless NHS doctors never asked about my diet.
https://baldmichael.substack.com/p/sodium-nitrite-e250-the-poison-in
Thank you for pointing out this extremely concerning effect of the benzimidazole anti-helminthic mechanism, namely its interference with both formation and function of microtubules, extending to the brain and nervous system, as you point out.
https://www.sciencedirect.com/science/article/pii/S0048969723039992?via%3Dihub
The use of this weak chemotherapy drug, dosed by its enthusiasts at 444 mg 1-2x/day caused new damage in the body that the fenben vendors seem to want to sweep away, as if the liver and brain were expendable.
There are many known ways to attack cancer with natural substances, https:NatOnco.org, and those have shown strong effect over decades https://NatureWorksBest.com.
Buyer beware of fenbendazole, a weak OTC chemotherapy, with its adverse effects on multiple organs.
Yes, no one really apprexiates the author with 17 year experience in cancer treatment honest scientific opinion, but instead talk around the subject. There is a huge diference with what wants to hear and what she is telling us. It is important to focus on liver enzymes and when and how the enzymes start to show elevation. Will it be when fenben is used on a daily basis for a certain amount.of days etc..
https://fenbendazole.substack.com addressed the elevated liver enzymes recently. Here is that presentation: Does Fenbendazole Cause Liver Damage?
Some have expressed concern that fenbendazole has been linked to liver injury. There is a report documenting the effect of fenbendazole on liver function as measured by the enzymes aspartate transaminase (AST) and alanine aminotransferase (ALT). A search using Google of “fenbendazole and cancer” returns this case report as the first result: Teppei Yamaguchi, Junichi Shimizu, Yuko Oya, Yoshitsugu Horio, Toyoaki Hida. Drug-Induced Liver Injury in a Patient with Nonsmall Cell Lung Cancer after the Self-Administration of Fenbendazole Based on Social Media Information. Case Rep Oncol 1 September 2021; 14 (2): 886–891. https://doi.org/10.1159/000516276
Elevated liver enzymes may actually be a good sign for a cancer patient taking fenbendazole. Those liver enzyme (AST, ALT) values may spike for one or two months as the liver is stressed by the influx of dead cancer cells as it filters and processes the cellular debris from those dead cancer cells. AST and ALT increasing is a sign of hepatic stress (work), not necessarily disease, in the context of fenbendazole use. These liver enzymes usually normalize after the cancer is eradicated by fenbendazole.
FYI, liver enzymes will also fluctuate with other noncancerous sicknesses/recoveries as dead cellular debris enters the bloodstream and is processed by the liver for removal. This is part of a normal physiological process. Temporary liver enzyme fluctuation should be expected to occur as a matter of course when using fenbendazole as fenbendazole kills the cancer cells.
Thanks for chiming in FenBen
I was hoping you would appear here
I appreciate you SS out of all of the SS’s around.
Fenbendazole also kills parasite (which are linked to cancer) so when you take the Fenbendazole you’re dealing with their toxic debris also.
I’m going to do Dr. Merrit’s protocol of alternating with Nitazoxanide and Fenbendazole. I’m assuming you’re talking about Fenbendazole?
I forgot to tell you that Methylene Blue also eradicates these things.
In a book I was just reading it says “The life cycle of parasites, bacteria, fungi and viruses are all in jeopardy when in the presence of Methylene Blue. And when used in combination with light therapy, Methylene Blue exerts even greater anti microbial effects against bacteria, like E. coli and others, including drug resistant strains, against fungi like Candida, and also against many common viruses, including Zika, West Nile, Ebola, Hepatitis and HIV.”
I take it every day now along with the anti parasitics and other things!
Thanks for the explanation. The more I learn about the liver this seems to make sense. Everything has to filter through the liver, hormones, etc. all the chemicals we have been in contact with over the years. It still functions, but slows down as we age because we don’t get rid of all that junk. Also, if the lymphatic System is clogged as we will have double the back up.
It’s imperative to clean up, detox and give the body extra support if your going to take anything new. Give the body what it needs during this time.
Just thinking as a lay person that likes to read and understand how things work, I’m not a Dr.
The liver has remarkable regenerative properties as well.
I’m learning this! Thanks for the confirmation. Our bodies are amazing if we would only listen to them.
Thanks Ben
☝️Bingo hardbody Ben Fen 🤠
I’ve shown you enough of these ALT/AST panels vacillating and returning to normal after monkey hammering tumors of all sorts into
Oblivion
I’ll let you inform this nice lady.
You have the bedside manner of a nice Dr
I’m a hard bastard and don’t won’t to have to blow this article outta the water with massive successes that include FBZ as one of the components coupled with liver panels where >80% of the people see no
Raised ast/alt levels
Then I’ve shown you elevated panels in less than 20% of the people that absolutely clear their soft tissue Cs
Blessings Ben
Other than drinking water, is there anything one can to do assist the body eliminating this dead cellular debris. Thanks.
Many experimental and clinical investigations have confirmed the hepatoprotective effect of extracts and their active components. Milk thistle (Silybum marianum) has many benefits, including antioxidant, anti-inflammatory, liver protection, and neuroprotective effects. A marked reduction in the plasma levels of liver enzymes such as ALT, AST, and ALP by silymarin has been repeatedly reported.
Milk thistle, green tea, and cinnamon are used in this study. Milk thistle was #1
https://brieflands.com/articles/tms-136000#:~:text=Milk%20thistle%20(Silybum%20marianum)%20has,reported%20(38%2D40).
https://www.medicinenet.com/what_is_milk_thistle_good_for_can_take_every_day/article.htm
I would take lots of Zeolite and Fulvic Acid!
Makes sense, i almost got a fright here.. i am only using fenben 3 days a month. I do have liver problems and gp's don't really discuss the functionality of the l iver but only wants to promote statins by doing so...or fatty liver.
If you have liverC you may have a proclivity for elevated liver enzymes already
At 4 on 3 off of FBZ
This will be minimally elevated
As your taking a 3 day regenerative liver break
Take a liver panel test every 1-3 months to be smart
I’d rather see elvated liver enzymes temporarily than watch carcinoembryonic antigens rising until the person dies
The liver can regenerate 90% of itself
Kinda like a lizards 🦎 tail
You might already know this but eating more choline (best sources are egg yolks and liver) and/or taking a choline supplement is a huge benefit for the liver. I take phosphatidyl choline as I have a genetic SNP that makes me require extra choline. Many people are deficient.
Is it the same as soy lesithin? And if i eat soy sprouts will it help?
Eating sprouts helps only a tiny bit because they contain only a fraction of the choline you need. 100 grams of sprouts (a large serving) contains 15 mg of choline while an egg yolk contains 147 mg.
If you've ever had genetic testing done, you can use this online calculator to see how much choline you need: https://chrismasterjohnphd.substack.com/p/how-much-choline-should-i-eat-the
But if that's too complicated, just err on the side of eating extra.
Chris Masterjohn (my favorite nutrition researcher) recommends the average person get 550 mg of choline per day but those with genetically higher requirements may need up to 1000 mg. I hope that helps.
Can you test for choline deficiency? I am fond of eggs, not so much liver, although ocassionally i do enjoy some liver. Will chicken liver also be good? Or will it be just red meat liver?
Unlike vitamin D and other vitamins, you can't test for choline with a blood test. The way choline deficiency is usually discovered is through elevated liver enzymes and fatty liver disease. Some people genetically need more choline than others. Here's a medical study that explains more: https://pubmed.ncbi.nlm.nih.gov/22134222/
Here's a quote from the study: "Humans eating low-choline diets develop fatty liver and liver damage. This dietary requirement for choline is modulated by estrogen and by single-nucleotide polymorphisms in specific genes of choline and folate metabolism. The spectrum of choline's effects on liver range from steatosis to development of hepatocarcinomas, and several mechanisms for these effects have been identified. They include abnormal phospholipid synthesis, defects in lipoprotein secretion, oxidative damage caused by mitochondrial dysfunction, and endoplasmic reticulum stress. Furthermore, the hepatic steatosis phenotype can be characterized more fully via metabolomic signatures and is influenced by the gut microbiome. Importantly, the intricate connection between liver function, one-carbon metabolism, and energy metabolism is just beginning to be elucidated."
You can get choline from chicken liver, beef liver, and lamb liver. I make sure to eat 4 eggs yolks every day as well as taking the choline supplement as I recover my health. You are right that choline is also found in soy lecithin. I bought a bottle and I add it sauces but it's a little strange and my family was less than thrilled last time I tried to sneak it in a recipe. I'm better off adding egg yolks to sauces.
I love my eggs, but ended up having less than normal, because my husband had a heart attack, AND 10 years later triple bypass after taking statins for years, and he still believes msm that eggs are poison for cholestrol. Maybe i should just pop raw eggs in a smoothy every day, egg white intact. Eggs are poison and statins are the magic treatment. I have high cholestrol but luckily i do not take statins, i am worse off when i tried to years ago. Swollen ankles like a michelin man in 2 weeks. My cholestrol is higher than my husband's. Only difference perhaps is he has a stressful job. Every time i visited my gp (don't visit them after these recent public lies though), he used to say i am going to die (fear nonsense again) ifni don'tbuse the strongest statin, onto whichni sad (i don't want your statins of medicine (because if i do, i will have to take water pills and develop high blood pressure eventually) ," i am only interested in your diagnosis", which made him furious. So, i have my fair share in distrusting mainstream drs.. sorry, they have to go back to school and learn about prevention as well, but then it will kill their symptom treating money making machine.
Thank you! I have learned 1000 % more from you than from my internist who only said "ma'am, stay away from purine and fat". After being scared into coming for regular check-ups after being initially diagnosed with black liver hemangiomas and cysts, they ended up hooking you in with 6 months visits to the radiology dept and an "interpretation" visit scheduled at your internist, telling you nada about techniques like choline... what a waste of time. I was just feeding them money to keep up their lifestyles and wash each other's backs. What a legitimate joke. And i am the sucker. And driving 1000 km to discuss the radiology report tellkng me again to stay away from red meat (like gout), having a faulty/battling liver end up having gout, and since they only treat symptoms and not cause, it is a never ending cycle.
The truly surprising thing is that medical schools teach almost nothing about human nutrition--only how to prescribe drugs! The sad thing is that 100 years ago, most doctors were integrative but Rockefeller bought out all the medical schools and began controlling their curriculum to sell pharmaceuticals. But one thing that makes me so excited is that we have access to ancient healing strategies like nutrition, fasting, and ketosis. I was able to reverse my type 2 diabetes, heal migraines of 25 years, and put an autoimmune disease into remission just by practicing intermittent fasting, eating more protein including red meat, cutting seed oils and reducing carbs, and taking some key supplements such as choline, B vitamins, and cod liver oil.
One more thing: I can't remember if I already said this or not but you also need the amino acid glycine for liver health. You should be able to buy it in powder form and add it to tea or coffee (or anything). It's slightly sweet. It also helps skin.
https://pubmed.ncbi.nlm.nih.gov/33268508/
Time and time again i tried tcm, for e.g. panaxea oool blue, and i end up with liver pains, same with berberine. It is kind of hard to get single products in south africa, so i could only get hold of berberine complex (chromium, milk thistle and berberin). Always ending up not to know which of these supplements are harming my liver/making my liver battle. These supplements also cost us a fortune in our country, since most are imported. I ended up being able to purchase grounded milk thistle, but don't know how much and how often.
In this 2-minute video, Dr. Ken Berry explains how l-carnitine, found in red meat, can improve liver function: https://www.youtube.com/watch?v=he1spfDb7Q0
Here's another great video about liver health and choline: https://www.youtube.com/watch?v=XGq7-asWQlg
What is one carbon metabolism, aa well as estrogen.status, why is it important to know?
I just thought of one more thing. If you ever struggle with fat digestion, choline helps with that as well.
Many experimental and clinical investigations have confirmed the hepatoprotective effect of extracts and their active components. Milk thistle (Silybum marianum) has many benefits, including antioxidant, anti-inflammatory, liver protection, and neuroprotective effects. A marked reduction in the plasma levels of liver enzymes such as ALT, AST, and ALP by silymarin has been repeatedly reported.
Milk thistle, green tea and cinnamon were used in this study... Milk thistle was #1
https://brieflands.com/articles/tms-136000#:~:text=Milk%20thistle%20(Silybum%20marianum)%20has,reported%20(38%2D40).
https://www.medicinenet.com/what_is_milk_thistle_good_for_can_take_every_day/article.htm
Very interesting!
You are overstating liver damage caused by fenbendazole that is actually more common as a problem in animals and is a rare side effect in humans. I do agree that that no magic bullet exists for any disease and a holisitc approach is called for. As a care giver thanks to Fenbendazole I was able to bring back a stage 3 Multiple Myeloma patient who correctly rejected a toxic chemo therapy/useless stem cell approach (harvesting his own stem cells) who was given a grim prognosis of 2 months to live to100 percent full remission in seven months.
However, it called for much more than just Fenbendazole. I had to make sure that his glucose intake was eliminated ie - he enjoyed a few bottles of wine ever day that i convinecd him needed to be eliminated and substituted this with canaboid oil that also has some anticancer properties and had a way of relieving his anxiety.
Substituting sugar with allulose was crucial. supplementing vitamins etc and the list goes on.
i am a fan of the Warburg effect and little doubt in my mind that cancer is a metabolic disorder.
Hence depriving hypoxic cancer cells of glucose and glutamite that resort to mitochondria relying on fermentation to produce energy via lactate instead of oxidative phosphorylation generating AtP is crucial.
Are you going to tell us next that these Dr's at Stanford that studied these three patients who were at death's door and saved by Fenbendazole are promoting "street drugs"?
https://www.scitechnol.com/peer-review/fenbendazole-enhancing-antitumor-effect-a-case-series-2Kms.php?article_id=14307
"he enjoyed a few bottles of wine every day" 😮
🫡
👍
Substitute glycine for sugar.
ALLULOSE - also known as D-allulose or D-psicose, is a sugar that occurs naturally in some foods, but it can also be made from fructose as a commercial food product using enzymes to convert fructose into allulose.
Allulose is classified as a rare sugar because it is naturally present in only a few foods - wheat, figs, jackfruit, maple syrup and molasses. Like glucose and fructose, allulose is a monosaccharide, or single sugar. In contrast, table sugar, also known as sucrose, is a disaccharide made of glucose and fructose joined together. Allulose has the same chemical formula as fructose but is arranged differently. This difference in structure prevents your body from processing allulose the way it processes fructose. Although around 70% of the consumed allulose is absorbed into the blood through the digestive tract, allulose leaves the body via urine, without being used as fuel. Allulose also provides only 0.2–0.4 calories per gram, or about 1/10 the calories of table sugar. Allulose does not raise blood sugar or insulin levels.
Research suggests that allulose has anti-inflammatory properties and may help prevent obesity, reduce the risk of chronic disease and is a powerful tool for managing diabetes. Several animal studies have found that it may lower blood sugar, increase insulin sensitivity, and decrease the risk of type 2 diabetes by protecting the insulin-producing beta cells of the pancreas. Research also suggests that allulose may have beneficial effects on blood sugar regulation in humans.
Furthermore, research suggests that allulose may help increase the loss of fat, including unhealthy belly fat, which is also known as visceral fat. This type of fat is strongly linked to heart disease and some other health conditions. A study of healthy adults found that taking 5 g of allulose before a meal appeared to lead to improved energy metabolism after they ate, which could help manage body weight. In addition to preventing weight gain, allulose seems to reduce fat storage in the liver. Hepatic steatosis, more commonly known as fatty liver, is strongly linked to insulin resistance and type 2 diabetes. In one study, mice with leptin deficiency and obesity were given allulose and showed lower total fat mass and liver fat after 15 weeks. These changes occurred without exercise or restrictive diets.
While it promotes fat loss in the liver and body, allulose may also protect against muscle loss. In the same study of mice with obesity, allulose significantly decreased liver and belly fat and appeared to prevent the loss of lean mass.
Allulose has been added to the list of foods generally recognized as safe by the Food and Drug Administration.
The same mechanisimns of denying the fermenting cells glucose apply to cancer as they apply to diabetes 2.
An interesting sugar, but I believe glycine does most if not all of that, and also does more - lots of health benefits. I use around 10 g per day.
1) Skin Health
Glycine (through the consumption of collagen) significantly improved skin elasticity in elderly women and improved skin moisture and water loss [4, 5].
Collagen peptide, which contains a lot of glycine, suppressed UV-B induced skin damage and photoaging [6].
Women taking 2.5g of collagen peptide for 4 weeks significantly reduced eye wrinkles by 20%, with positive effects lasting after the study ended [7].
At 8 weeks, collagen significantly improved skin content of procollagen type I by 65%, and elastin by 18%.
Diabetic Ulcers
Glycine nearly doubles the speed at which skin ulcers heal in 89 diabetic patients across 23 long term care facilities [8].
Glycine enhanced wound healing in diabetic animal models as well [9].
Glycine in combination with l-cysteine and dl-threonine topically applied to leg ulcerations significantly improved the degree of wound healing and decreased pain [10].
Glycine’s best evidence of benefit comes for its effect on diabetic leg ulcers. Nevertheless, additional research is required before it will be considered sufficient to support a medical claim.
2) Mental Illnesses
Schizophrenia
Glycine supplementation significantly reduced symptoms of schizophrenia [11].
In treatment-resistant schizophrenia glycine improved cognitive and depressive symptoms (dosed at 0.8g/kg).
The group who made the most improvement were also the most deficient in glycine [12].
Glycine helps in chronic schizophrenia by increasing NMDA-receptor-mediated neurotransmission [13].
This effect on NMDA-receptor-mediated neurotransmission allows for glycine to work synergistically with schizophrenia medication [11].
OCD
Glycine supplementation has been shown in one instance over the course of 5 years to significantly reduce symptoms of OCD and body dysmorphic disorder [14].
Glycine has positive results when used in the treatment of obsessive-compulsive disorder in adults [15].
Depression
Depression is associated with lower levels of blood glycine, as well as high levels of taurine [16].
Glycine is most likely to be beneficial for people with schizophrenia and could be beneficial for people with other types of mental illness. Additional human trials will be required to determine glycine’s potential role in mental health.
3) Brain Health
Small amounts of glycine have been shown to dilate the microvessels in the brain by up to 250% [17, 18].
In rats with alcohol poisoning, glycine was able to reduce the accumulation of cholesterol, free fatty acids, and triglycerides in blood circulation, liver, and brain. Ultimately, this decreases swelling in the brain [19].
A shortage of glycine in the brain can negatively influence the brain neurochemistry, synthesis of collagen, RNA/DNA, porphyrins, and other important metabolites [20].
Stroke
In ischemic stroke patients, taking glycine 1 – 2g/day normalized autoantibodies, reduced glutamate and aspartate levels, increased GABA concentrations, and reduces lipid peroxidation [21].
Those who consume regularly low doses of glycine actually reduce damage in future strokes [21].
The glycine treatment at the dose of 1 – 2g/day was accompanied by a tendency to a decreased risk of dying over 30-days [21].
500mg/kg glycine combined with 500mg/kg Piracetam improved cognitive impairments and promoted recovery in the prefrontal cortex in animals with a stroke [22].
There is relatively good evidence that glycine could play a role in stroke prevention and recovery; larger, more robust, and more specific human trials will be required.
Insufficient Evidence For
The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of glycine supplements for any of the below-listed uses. Remember to speak with a doctor before taking glycine supplements, and never use them in place of something your doctor recommends or prescribes.
4) Sleep and Fatigue
Taking glycine before sleep improves sleep quality and sleep efficacy by shortening the time to fall asleep while increasing restorative, slow-wave deep sleep [23].
After taking glycine for sleep, the following day subjects had lessened daytime sleepiness and improved performance of memory recognition tasks [23].
Glycine helps improve REM sleep and decrease non-REM sleep [24].
3g Glycine given to volunteers before sleeping resulted in improvements in fatigue, ‘liveliness and peppiness,’ and ‘clear-headedness’ [25].
Glycine appears to improve daytime sleepiness and fatigue induced by sleep deprivation [26].
Glycine affects certain neuropeptides in the SCN (suprachiasmatic nucleus) in the region in the hippocampus which regulate the circadian rhythm [26].
Specifically, glycine increases VIP, which is critical to the circadian rhythm.
This effect on the SCN indirectly contributes to reducing sleepiness and fatigue induced by sleep restriction [26].
In clinical studies, glycine supplementation reduced daytime sleepiness and fatigue and made people feel more lively and clear-headed after sleep deprivation.
5) Gut Health and Ulcers
Glycine dramatically increased the tolerability of Aspirin in the upper GI tract of 20 healthy human volunteers [27].
Glycine inhibits stomach acid secretion and protects against chemical and stress-induced ulcers [28].
Glycine possesses significant anti-ulcer activity [29].
Glycine prevents chemically induced colitis in animal models [29].
Glycine prevents alcohol-induced stomach lesions (ex. ulcers) when used as a pretreatment in animal models [30].
In small intestine grafts, glycine improves smooth muscle dysfunction after transplantation as well as reduces inflammation [31].
Glycine, but not L-arginine, is able to maintain intestinal wall integrity and mucosa in cancer treatment irradiation in animal models [32].
Glycine has protective effects against oxidative stress in intestinal cells in test tubes [33].
Glycine could potentially help prevent the formation of ulcers in response to stress or harmful chemicals, but human studies have been very limited.
6) Metabolic Disorders
5g glycine taken in the morning increased total insulin response in 12 healthy first-degree relatives of Type 2 diabetes patients [34].
Glycine is believed to help with diabetes and metabolic disorders [2].
Glycine intake decreases free fatty acids in blood, fat tissue cell size, and blood pressure in sucrose-fed rats [35].
Glycine reduces glycated hemoglobin (A1C), a risk factor associated with poor blood glucose management in patients with type 2 diabetes. The dose was 5g/d [36].
Glycine stimulates the secretion of a gut hormone (glucagon) that helps insulin to remove glucose from circulation [37].
Glycine helps patients with oxidative stress in the development of metabolic syndrome [38].
Glycine increases adiponectin, which may trigger weight loss in obese people, but this effect has only been observed in a cell study [39].
Glycine is considered important for metabolic health, but much of the research on this topic is limited to animals and cells.
7) Glucose Balance & Diabetes
Diabetic patients have 26% lower blood glycine levels than “normal” population [40].
Glycine helped 8 older, male HIV patients restore insulin sensitivity [41].
Glutathione synthesis was restored in patients with uncontrolled diabetes and hyperglycemia with glycine (+cysteine) added to their diet [42].
Glycine helps with lipid profiles in insulin-resistant patients (but not insulin resistance).
Glycine can help with positive glucose management by stimulating the production of Glucagon, a hormone which helps potentiate the action of insulin [37].
These early studies are promising, but larger and more robust human trials are needed.
People with diabetes appear to have lower blood glycine than the average, and glycine supplementation improved insulin sensitivity and glutathione synthesis in diabetic patients.
8) Heart Health
Glycine lowered systolic blood pressure in 60 patients with metabolic syndrome [38, 41].
In heart attack conditions (Post-ischaemic reperfusion) glycine prevented the death of heart muscle cells by inhibiting mitochondrial permeability in rats [43].
Glycine depletion within cells during a heart attack (hypoxia/reoxygenation) may make heart cells more vulnerable to cell death [43].
Glycine lowered blood pressure in patients with metabolic syndrome; glycine’s role in heart health has otherwise not yet been studied in humans.
9) Joint, Bone, and Muscle Strength
Glycine improved body composition and muscle strength in 8 older men with HIV [41].
Glycine protected against (peptidoglycan polysaccharide-induced) arthritis in animal studies [28].
Glycine combined with green tea benefits tendon recovery processes after tendinitis by better collagen bundling organization [44].
Glycine can potentially help in menopause because of its estrogen-like bone protective effects [45].
Glycine played a role in maintaining the health of mice suffering from osteoarthritis [45].
Glycine is believed to be important for joint, bone, and tissue strength. High-quality human research into this potential benefit is lacking.
While glycine is an important nutrient with potential health benefits, it is not directly comparable to Allulose in terms of its effects on cancer cell metabolism or the Warburg effect. . Both glycine and allulose may have their respective places in nutrition and therapeutics, but they are not interchangeable, and their roles should not be conflated.
Just bought some allulose.
I take it daily at night and love it.
Where to purchase a good quality? Thank you.
Ive tried pure encapsulation glycine because I get a practitioner discount and bulk supplements glycine. I couldn’t tell the difference so stuck with bulk supplements.
Where is this article originally?
https://selfhacked.com/blog/glycine-little-protein/
Thank you for this great info! I’m 60, take a high quality collagen (Designs for Health) which has three different types of collagen in it. A serving has 12.5g collagen. If people take this, do they also need to take amino acids? Sometimes I’ll take amino acids before strength training. Not sure if this is too much or if they work differently?
You always have such helpful information. I appreciate the time and energy that you put in. Many of us are people that completely trusted our beloved doctors. We are now lost and scrambling for true information. I so need an uncaptured doctor but I can't seem to find any. I feel so lost because no one believes me about the shots, my heart feels broken. Anyway I appreciate you!
God bless you 🙏
Sid - This is fascinating! Do you have more info on allulose and/or any links to studies or articles? I would love this for myself and to pass along to a couple of other people. I believe you need a substack of your own:)
I am also a big believer in the benefits of glycine, and I supplement with 6 grams daily.
Why 6 grams? Why not 5 or 10 or 30 grams? 6 grams sounds like you're measuring it out which is not at all necessary. It's safe up to (and probably beyond) 60 grams.
I throw it on everything, burgers, kimchi, cottage cheese, in coffee. Don't know how much but around 15 grams with no prob. I also believe that the same dose everyday is not natural.
More of a good thing is usually better, despite what people say, although one must always be reasonable. Don't be afraid to experiment - nutrients are not drugs - they won't kill you. Go wild.
I prefer pure organic stevia and eat only whole foods with little to no carbs.
Eliminating sweeteners altogether is also an option. Takes a few months to get over the craving, but then it's no big deal.
I agree!
Can we stop posting references of studies with conflicts of interest from big pharma? And more details on elevated liver enzymes would help, like were they taking more fenben than they should be taking?
My great-grandmother told me that laughter is the best medicine and she lived to 92 after being bitten by a rattlesnake as a young girl. She was engaged to the founder of the Dr. Pepper Co. but broke her engagement and ran off with a railroad man. There went my chance to be a big soda pop typhoon.
Tycoon. Unless you are a big wind. 😉
Listen to Tom Smothers on the Purple Onion album.
Gotcha!
What was the dose and duration of fenbendazole for those incredibly high liver enzyme numbers to develop?
Unless the administration dosage and protocol is disclosed those numbers could be caused by acetaminophen (Tylenol)
Acetaminophen i can be nasty stuff. When my son was four, he had a cold that (unbeknownst to me) progressed to pneumonia. I was giving him an over-the-counter pediatric cough/cold medication that contained acetaminophen. Long story short, he was life-flighted to an urban pediatric hospital, and after a couple of days where they did a liver biopsy and were talking possible transplant, his liver, which had been 30% dead according to the liver specialist, staged a miraculous recovery in record time. The specialist later calculated that he had been getting a 1/3 dose of acetaminophen for his body weight but since he was weakened from the pneumonia, it drastically affected his liver. This is the same thing that happens to alcoholics.
Fast thinking saved him! Acetaminophen is in many different OTC remedies. If we lived in a just workd it would have bewn removed from the market for safety and redundancy issues many years ago.
Actually, his pediatrician did extra testing and discovered unusual liver numbers, at which point he was life-flighted. That was the fast thinking for which I'll be forever grateful. Once he was hospitalized, of course, he quit getting the OTC crap. Before they figured out what had caused the problem, the specialists were asking me if he could've gotten into any wild mushrooms (in Utah! In January!) or the like.
I did have a lawyer look into some sort of legal action, not for ourselves, but because I was appalled such a dangerous substance is getting popped like candy by the general public thinking it's safe. As I now know, Pharma has ways of covering their ass.
I hope Joe Rogan has you on his podcast soon. I’m sure you would have a good discussion and many people would benefit. (But if you do, I hope you know of docs who practice similarly to you around the US / globe, so you aren’t slammed with requests.)
Does anyone on this substack know anything about natural treatment for recurrent UTI?I have had info from a friend regarding a product call UQORA. I have researched it. The gist of their product is to prevent bacteria clinging to the wall of the bladder. Would appreciate anyone’s referral for info. Thank you in advance.
Cranberry tablets (the sweetened juice is no good).
D-mannose
A probiotic containing Lactobacillus rhamnosus and Lactobacillus reuteri
Thank you.
No worries.
If it's acute then the best thing is to alkalise the urine. Drinking a large glass of water with a teaspoon of potassium citrate or plain old sodium bicarbonate stirred in will help.
UroFem D Mannose. I know several people, including my mum who have had excellent results preventing recurrent uti. I don't know anything of other brands.
Thank you just bought some.
You are so welcome. I also know some urologists are now recommending it.
Methylene blue
I use methylene blue which was the standard of care for UTIs before antibiotics were invented. I bought it on Amazon and put one dropper into a glass of water. If you take it straight it will stain your teeth and tongue blue but not if you dilute it.
Dr Grouf has a protocol. My mother gets them frequently as well. https://open.substack.com/pub/doctorgrouf/p/grouf-uti-urinary-tract-infection?utm_source=share&utm_medium=android&r=p12mg
Does this protocol work for her cause that’s a whole lot of money and supplements to invest in for a uti.
Honestly, I have not used it and I just found it so I really don't know. She's really tough about taking supplements and eating well but if it was me I would probably try it. Her biggest issue is she's become antibiotic resistant.
Oregano oil capsules
There’s a private Facebook page that addresses this. I don’t know that much about it.
Dr. Gerson found his cancer patients were dying, not of the cancer rather due to hepatotoxicity. He added coffee enemas to the protocol, and his patients stopped dying.
Can you show the blood labs before and after some standard chemo agents to compare with fenben?
Also, why is fenben disqualified because it's a "monomolecular approach"? Is it uniquely unable to be combined with other drugs?
Thanks so much for writing this. I keep seeing comments and advertisements for fenbendazole and wondered where the studies were for how safe and effective it is. Also thanks for the link to the natural treatment website.
Thank you! What do your think of this:
12 Metabolic Interventions to Control Cancer
42% of newly diagnosed cancers in the US are potentially avoidable. These simple adjuncts such as lifestyle changes, supplements and drugs can help you manage and "starve" cancer:
1. Low-carb, high-fat, ketogenic diet plus time-restricted eating (intermittent fasting).
2. Exercise, stress reduction, and obtaining quality sleep.
3. Vitamin D3: 20,000-50,000 IU daily1
4. Melatonin: start 1 mg and increase to 20-30 mg nightly (extended/slow release)
5. Green Tea catechin, epigallocatechin-3-gallate (EGCG): 500-1000 mg/day
6. Metformin: 1,000 mg twice daily
7. Curcumin (nanocurcumin): 600 mg twice daily
8. Mebendazole: 100-200 mg daily
9. Omega-3 fatty acids: 4 g daily
10. Berberine: 500-600 mg twice daily
11. Atorvastatin: 40 mg twice daily (or Simvastatin 20 mg twice daily)
12. Disulfiram: 80 mg three times daily or 500 mg once daily
Cancer and Spike Protein: What’s the Link
As planned from scratch, there's CANCER written all over the COVID attack:
a) Spike protein (from COVID and from haccines):
1. Included a sequence of a cancer Moderna patent
2. Interfered with the repair mechanisms of DNA 2
3. Interfered with tumor suppressor protein BCRA and p53, the blocking of p53, causing lymphoma, breast, ovarian, and pancreatic cancers. 3
4. Lipid nanoparticles are carcinogenic
5. HIV sequence in the spike protein deactivates the immune system against the abnormal proliferating cells.
c) Pfizer included a partial sequence of carcinogenic monkey virus SV40
Why did they deliberately cause cancer?:
https://open.substack.com/pub/scientificprogress/p/system-failure-ai-exposes-zero-government
Best cures for cancer in days
“Heart disease, cancer, medical errors and abuse, accidents, stroke, Alzheimer’s, and diabetes are the main causes of death. These are all preventable. The cure is ‘studying’.”
The cures for cancer (or any other disease, even if rare), could be found in days, if already in use: all we need is the physicians, hospitals, ministries of health, patients or their survivors, to upload the clinical records of what they already used to treat their patients to a standardized database which applies real-time multi-linear regression:
• disease stage when treatment begun
• not the prescribed but real life dose/kg and uptake frequency of medicines/food/nutrients/nutraceuticals
• changes in relevant lifestyle data (exercise, sleeping, etc.)
• disease evolution
• survival phases
Also, the platform will help discard current treatments which actually harm or kill patients (e.g. remdesivir, injections).
There could be prizes for the most effective treatments, reproduced by other doctors.
There should be a procedure to eliminate or reduce fake data, for example, to check the uploaded photos of documents proving the data.
There should be a medical social network for collaboration and dissemination.
We could have done it with COVID treatments! We should prepare the platform for the next PLANNEDemics.
How about crowdfunding?
Big mammoth in the room: why hasn’t any government done this? !!!
https://scientificprogress.substack.com/p/the-plan-revealed
You can and should do far more melatonin than that - I take 120 mg or 180 mg per night. it's not a soporific, it's an antioxidant, many times better than vitamin C because it's metabolites and metabolites of metabolites continue to scavenge and neutralize free radicals.
Re: melatonin - Some people may experience hallucinations.
Haven’t heard of that - dreams are interesting. Look up the top researcher Dr Reiter.
Thanks! Got this, should anyone else be interested:
https://www.onedaymd.com/2022/08/what-you-need-to-know-about-melatonin.html
Also look up Reiter on YouTube.
Amazon has 60 mg caps of melatonin. For sleep, 0.3 mg may be best. There is no effect of high-dose melatonin on your body's natural production of melatonin. That's not a concern, it does not interfere short- or long-term.
That article mentions near infrared wavelengths stimulating melatonin in cells. Maybe so, but I had a friend who did mice research on cancer at Mass General and the one cohort of mice that had infrared therapy all died. No need to bake under red lights - just dose up with melatonin.
From that linked article: "“I'm going to give you a very specific example,” Reiter says. “Here's a local physician, Dr. Richard Neil, whom I have known for a number of years. When COVID-19 became common, he called me, we discussed it, he started giving 1 mg per kilogram of body weight (once a day) for about five days, at the time of diagnosis. He has now treated more than 2,000 patients, very successfully, with melatonin."
There are apparently many cures for covid but the doctors don't know any of them.
Why both metformin and berberine? The latter should be enough on its own, I believe.
If you had a patient come in with toxicity from acetaminophen, what's the first question? "What dosage was the patient taking?" of course.
This article seems to highlight on instances where patients were possibly taking dosages outside the typical "Tippens Protocol" recommendation of 222mg Fenben 3 days on, 4 days off.
Regarding the patient bloodwork prominently posted in this article...Dr Huber, you note in another comment: "My understanding is that the patient was taking 1 or 2 caps per day, uncertain of dose, for some weeks and for most days, until we implored stopping it. This was from an online vendor. Then the liver labs started moving toward normal." So...the patient dosage was unknown.
When I look online at such as Amazon, I see they sell both 222mg and 444mg Fenben capsules...I really don't know why they sell the 444mg, when it's double the typical protocol.
In other words, the patient was taking perhaps 222mg most days...or possibly 444mg depending on the caps...or possibly (when taking 2 caps) 444mg or 888mg ... in other words, it's unknown the dosage the patient was taking, and taking that unknown on contiguous days. In other words, the patient could've been taking 1-4X or more possibly the recommended dosage/day. And if taking a higher dosage every single day without the typical 3 days on, 4 days off, it seems unsurprising that toxicity could occur.
Or take #3 referenced link from NIH, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255718/ - when a person digs in, it says: "She stated her fenbendazole schedule consisted of 1 g/day PO for 3 days, followed by 4 days off, and this schedule had been maintained for approximately 1 month from early July until her August visit. We stopped fenbendazole administration immediately, and her liver function parameters gradually improved."
In other words, this patient was taking the standard 3 days on, 4 days off protocol...but at 1g/day, she was taking 4.5X the recommended 222mg dosage. Correct me if I'm off base, but taking 4.5X recommended dosage of most anything can have adverse effects, correct? Please try taking 4.5X of acetaminophen ... no, just kidding, please don't!!!! But therefore, should we demonize acetaminophen because it's possible to take damaging dosages.
I'd have found this article much higher on the validity scale if I didn't have to dig in and locate these hidden facts, that should've been prominently noted as "when taking ANYTHING don't mess around with higher dosages/frequency than recommended." Disclaimer: I've been taking the standard Fenben protocol most weeks for the last two years or so, some weeks off here and there. I had a right radical nephrectomy for renal cell carcinoma over 5.5yrs ago, and I added Fenben as part of my protocol to help prevent recurrence. I also daily take NAC, SAM-e, C, garlic, etc ... items that happen to be liver supportive among with other other benefits.